Liproxstatin-1 hydrochloride 是一种有效的 ferroptosis 抑制剂，可抑制 ferroptotic 细胞死亡 (IC50=22 nM)。
货号:ajcx27386
CAS:N/A
分子式:C19H21ClN4.HCl
分子量：377.31
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Friedmann Angeli et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 16 1180 PMID:25402683