A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
货号:ajcx23352
CAS:34210-11-2
分子式:C20H30D4O5
分子量：358.5
溶解度:10 mM Na2CO3: >6.5 mg/ml (from PGF2a),DMF: >100 mg/ml (from PGF2a),DMSO: >100 mg/ml (from PGF2a),Ethanol: >100 mg/ml (from PGF2a),PBS pH 7.2: >10 mg/ml (from PGF2a)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Prostaglandin F_2α-d₄(PGF_2α-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF_2αby GC-or LC-mass spectrometry. PGF_2αis a widely distributed prostaglandin occurring in many species.^1,2,3It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exerts potent luteolytic activity.¹PGF_2αexhibits its receptor mediated physiological activity at 50-100 nM.¹Maximal ovine myometrial contraction can be achieved at 125 nM PGF_2αin vitro.⁴

1.Samuelsson, B., Goldyne, M., GranstrÖm, E., et al.Prostaglandins and thromboxanesAnnu. Rev. Biochem.47997-1029(1978) 2.Speroff, L., and Ramwell, P.W.Prostaglandins in reproductive physiologyAm. J. Obstet. Gynecol.107(7)1111-1130(1970) 3.Watanabe, K., Iguchi, Y., Iguchi, S., et al.Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2α by bovine lung prostaglandin F synthaseProc. Natl. Acad. Sci. U.S.A.83(6)1583-1587(1986) 4.Crankshaw, D.J., and Gaspar, V.Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewesJ. Reprod. Fertil.103(1)55-61(1995)