An mPGES-1 inhibitor
货号:ajcx21456
CAS:2253745-78-5
分子式:C27H25F2N3O
分子量：445.5
溶解度:Chloroform: 10 mg/ml,Ethanol: 10 mg/ml,Methyl Acetate: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC₅₀s = 66 and 2,730 nM for the human and mouse enzymes, respectively).¹It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E₂production in mouse peritoneal cells (IC₅₀= 12 nM).In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.

1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)