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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α图片
规格:98%
分子量:460.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An ocular hypotensive agent
货号:ajcx21158
CAS:1027401-98-4
分子式:C24H35F3O5
分子量:460.5
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 2 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin Fderivatives have been approved for the treatment of glaucoma.1,2,3These "ring" prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF(17-TFM-PGF) is a typical "ring" analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGFis saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the "ring" series of analogs, this modification has little impact on FP receptor binding.5As an ocular hypotensive agent, it is expected that 17-TFM-PGFwould act very much like the free acid of latanoprost.


1.Woodward, D.F., Krauss, A.H.P., Chen, J., et al.The pharmacology of Bimatoprost (LumiganTM)Survey of Ophthalmology45S337-S345(2001) 2.Stjernschantz, J.W.From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lectureInvestigative Ophthalmology & Visual Science42(6)1134-1145(2001) 3.Sorbera, L.A., and CastaÑer, J.TravoprostDrugs Future25(1)41-45(2000) 4.Resul, B., Stjernschantz, J., No, K., et al.Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agentsJournal of Medicinal Chemistry36243-248(1993) 5.deLong, M.A., Amburgey, J., Taylor, C., et al.Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analoguesBioorganic & Medicinal Chemistry Letters101519-1522(2000)