SQ609 是一种来自二哌啶库的先导化合物。SQ609 在 4μg/ml时抑制 90% 以上的细胞内细菌生长，并且对这些细胞有毒。SQ609 显示出强大的抗结核活性。
货号:ajcx33728
CAS:627052-25-9
分子式:C22H38N2O
分子量：346.55
溶解度:DMSO : 6.67 mg/mL (19.25 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1].

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells[1].

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1].

[1]. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357.