Pomalidomide-PEG2-azide是一种合成的E3连接酶配体-linker偶联物(E3ligaseligand-linkerconjugate)，包含基于Pomalidomide的cereblon配体和2个单元PEG的linker。
货号:ajcx32118
CAS:2267306-14-7
分子式:C19H20N6O7
分子量：444.4
溶解度:DMSO: 90 mg/mL (202.52 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.