PTP1B-IN-9是通过抑制20S蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生的泛素-蛋白酶体系统(UPS)应激源。PTP1B-IN-9在不影响20S蛋白酶体催化活性的情况下触发泛素蛋白酶体系统(UPS)应激反应。
货号:ajcx31362
CAS:145888-79-5
分子式:C19H13Cl4NO
分子量：413.12
溶解度:DMSO: 5 mg/mL (12.10 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].

PTP1B-IN-9 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively[1].PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM[1]. Cell Viability Assay[1] Cell Line: Keratinocytes, SiHa, CaSki and ME180 cells

[1]. Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.