Mc-Val-Cit-PAB-Cl是一种可降解的ADClinker，可用于连接MMAE和抗体，从而形成抗体-MC-vc-MMAE(如anti-CD22-MC-VC-PABC-MMAE，对BJAB和WSU具有细胞毒性，IC50分别为3.3nM和0.95nM)。
货号:ajcx31006
CAS:1639351-92-0
分子式:C28H39ClN6O6
分子量：591.1
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.