A muscarinic M2 agonist
货号:ajcx25590
CAS:116511-28-5
分子式:C10H13NO2·HBr
分子量：260.1
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Arecaidine propargyl ester is an agonist of M₂muscarinic acetylcholine receptors (mAChRs).¹It selectively binds to M₂over M₁, M₃, M₄, and M₅mAChRs in CHO cells expressing the human receptors (K_is = 0.0871, 1.23, 0.851, 0.977, and 0.933 µM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD₂= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 µM.²Arecaidine propargyl ester decreases mean arterial blood pressure in normotensive cats (ED₂₅= 1.9 nmol/kg).³It is toxic to house flies (Musca) when administered at a dose of 75 µg/fly.⁴

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