An essential cofactor in enzymatic acetyl transfer reactions
货号:ajcx22120
CAS:N/A
分子式:C21H33N7O16P3S.3Li [XH2O]
分子量：785.3
溶解度:PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism.¹About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a five-step process that requires ATP.²The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.³

1.Leonardi, R., Zhang, Y.M., Rock, C.O., et al.Coenzyme A: Back in actionProg. Lipid Res.44(2-3)125-153(2005) 2.Jackowski, S.Biosynthesis of pantothenic acid and coenzyme AEscherichia coli and Salmonella typhimurium: Cellular and molecular biology687-694(1996) 3.Begley, T.P., Kinsland, C., and Strauss, E.The biosynthesis of coenzyme A in bacteriaVitamins and Hormones61157-171(2001)