A very long-chain atypical ceramide
货号:ajcx20558
CAS:1645269-61-9
分子式:C42H83NO2
分子量：634.1
溶解度:DMF: >20 mg/ml,DMSO: >20 mg/ml,Ethanol: >30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml,PBS (pH 7.2): >50µ g/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C24 1-Deoxyceramide (m18:1/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(4E)) backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 1-Deoxyceramide (m18:1/24:0) has been found as a major deoxyceramide species in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3

|1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).|3. Alecu, I., Tedeschi, A., Behler, N., et al. Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J. Lipid. Res. 58(1), 42-59 (2017).