Uridine triacetate (Tri-O-acetyl uridine) 是尿苷的口服前药。Uridine triacetate (Tri-O-acetyl uridine) 脂溶性强，在肠道内迅速吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate (Tri-O-acetyl uridine) 用于预防和治疗危及生命的 5-氟尿嘧啶和卡培他滨的毒性。Uridine triacetate (Tri-O-acetyl uridine) 提供高浓度尿苷，竞争与有毒 5-FU 代谢物。
货号:ajcx14584
CAS:4105-38-8
分子式:C15H18N2O9
分子量：370.31
溶解度:DMSO: ≥ 100 mg/mL (270.04 mM); H2O: 10 mg/mL (27.00 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Uridine triacetate (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate (Tri-O-acetyl uridine) is lipophilic, is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate (Tri-O-acetyl uridine) is uesd for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Uridine triacetate (Tri-O-acetyl uridine) delivers high concentrations of uridine, which competes with toxic 5-FU metabolites[1][2].

[1]. Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356. [2]. Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8.