FC131 TFA 是一种 CXCR4 拮抗剂，抑制 [125I]-SDF-1 与 CXCR4 结合，IC50 值为 4.5 nM，具有抗 HIV 的活性。
货号:ajcx13900
CAS:N/A
分子式:C38H48F3N11O8
分子量：843.85
溶解度:DMSO: 250 mg/mL (296.26 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity[1]. IC50: 4.5 nM ([125I]-SDF-1-CXCR4)[1]HIV-1[1]

[1]. Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48(2):380-91.