Islatravir(MK-8591)是一种核苷逆转录酶(reversetranscriptase)抑制剂，具有抗HIV-1活性，对HIV-1(WT)，HIV-1(M184V)，HIV-1(MDR)的EC50值分别为0.068nM，3.1nM和0.15nM。
货号:ajcx12782
CAS:865363-93-5
分子式:C12H12FN5O3
分子量：293.25
溶解度:DMSO: 20.83 mg/mL (71.03 mM; ultrasonic and adjust pH to 3 with HCl); H2O: 3.57 mg/mL (12.17 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1].

[1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43.