β-鹅膏菌素是有毒鹅膏菌中的一种环肽毒素。 β-Amanitin 抑制真核 RNA 聚合酶 II 和 III。 β-鹅膏菌素抑制蛋白质合成。 β-鹅膏菌素可用作抗体-药物偶联物 (ADC) 的细胞毒性成分。
货号:ajcx12074
CAS:21150-22-1
分子式:C39H53N9O15S
分子量：920.0
溶解度:1 mg/ml in Water
纯度：98%
存储：Store at -20°C
库存：现货

Background:

β-Amanitin is a cyclic peptide found in several species of the?Amanita?genus, as well as other poisonous fungi.1?It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.2,3?The biological activity of this toxin is similar to that of α-amanitin but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.4