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ML-SI1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML-SI1图片
规格:98%
分子量:449.37
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
ML-SI1 是一种非对映异构体的外消旋混合物,是一种 TRPML 抑制剂,对 TRPML1 的 IC50 值为 15 μM。
货号:ajcx12010
CAS:N/A
分子式:C??H??Cl?N?O?
分子量:449.37
溶解度:DMSO : 100 mg/mL (222.53 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1.

ML-SI1 is an inseparable racemic mixture of cis-/trans-isomers (55:45) in a short synthetic sequence and its inhibitory activity on hTRPML1 (and a weak effect on TRPML2) after activation with ML-SA1. Fura-2 based single cell calcium imaging experiments confirmed that the synthesized racemic ML-SI1 (10 μM) has an inhibitory effect on hTRPML1[1].

参考文献:
[1]. Charlotte Leser, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.