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N-Boc-PEG6-alcohol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Boc-PEG6-alcohol图片
规格:98%
分子量:381.46
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
N-Boc-PEG6-alcohol 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG6-alcohol 可用于合成一系列 PROTAC 分子。N-Boc-PEG6-alcohol 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
货号:ajcx37454
CAS:331242-61-6
分子式:C17H35NO8
分子量:381.46
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N-Boc-PEG6-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1.