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Mipomersen sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:N/A
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Mipomersen (sodium) 是二代 20 碱基硫代磷酸寡核苷酸,可靶向人源 apoB-100。
货号:ajcx37362
CAS:629167-92-6
分子式:N/A
分子量:N/A
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Mipomersen (sodium) is a second-generation 20-base phosphorothioate ASO targeted to human apoB-100[1][2].

Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2].Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2].

[1]. Philip Hair, et al. Mipomersen sodium: first global approval. Drugs. 2013 Apr;73(5):487-93.
[2]. Damon A Bell, et al. Mipomersen, an antisense apolipoprotein B synthesis inhibitor. Expert Opin Investig Drugs. 2011 Feb;20(2):265-72.