Ligustroside (Ligstroside) 是一种 secoiridoid 衍生物，在早期阿尔茨海默病 (AD) 和脑老化模型中的线粒体生物能量学方面表现出色，其机制可能不会干扰 Aβ 的产生。Ligustroside 显着抑制脂多糖激活的 RAW264.7 巨噬细胞中一氧化氮的产生。
货号:ajcx36724
CAS:35897-92-8
分子式:C25H32O12
分子量：524.51
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer’s disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages[1][2].

Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP695 cells[1].

Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer’s disease and brain ageing[1].

[1]. Grewal R, et al. Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer’s disease and brain ageing. Exp Neurol. 2020;328:113248. [2]. Liu J, et al. Chemical structures of constituents from the flowers of Osmanthus fragrans var. aurantiacus. J Nat Med. 2015;69(1):135-141.