Valategrast (R-411 free base) 是一种有效的口服活性整联蛋白 α4β1 (VLA-4) 和 α4β7 双重拮抗剂。Valategrast 可用于慢性阻塞性肺疾病 (COPD) 和哮喘的研究。
货号:ajcx35784
CAS:220847-86-9
分子式:C30H32Cl3N3O4
分子量：604.95
溶解度:DMSO : 170 mg/mL (281.01 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].

Valategrast contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].

[1]. Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100.
[2]. Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.