BPH-652 是 CrtM 的抑制剂，Ki 值为 1.5 nM，IC50 值为100-300 nM (S. aureus 色素形成)。
货号:ajcx35610
CAS:157124-84-0
分子式:C16H16K3O7PS
分子量：500.63
溶解度:H2O : 25 mg/mL (49.94 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1].

BPH-652 treatment (0.5 mg twice per day (days -1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P< 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group[1].

[1]. Liu CI, et al. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 7;319(5868):1391-4.