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L-Homopropargylglycine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Homopropargylglycine hydrochloride图片
规格:98%
分子量:163.6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
L-Homopropargylglycine hydrochloride 是一种 PROTAC linker,属于 alkyl chain 类,可用于合成 PROTAC 分子。L-Homopropargylglycine hydrochloride 是蛋氨酸的氨基酸类似物,含有炔烃部分,可与含 Alexa Fluor 的叠氮化物发生经典的点击化学反应。
货号:ajcx34910
CAS:942518-19-6
分子式:C6H10ClNO2
分子量:163.6
溶解度:DMSO : 125 mg/mL (764.06 mM; Need ultrasonic), ≤10mg/ml in PBS(pH7.2)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562.
[2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.