L-Homopropargylglycine hydrochloride 是一种 PROTAC linker，属于 alkyl chain 类，可用于合成 PROTAC 分子。L-Homopropargylglycine hydrochloride 是蛋氨酸的氨基酸类似物，含有炔烃部分，可与含 Alexa Fluor 的叠氮化物发生经典的点击化学反应。
货号:ajcx34910
CAS:942518-19-6
分子式:C6H10ClNO2
分子量：163.6
溶解度:DMSO : 125 mg/mL (764.06 mM; Need ultrasonic), ≤10mg/ml in PBS(pH7.2)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562.
[2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.