GET73 是一种天然神经递质 γ-羟基丁酸 (GHB) 的类似物。GET73 具有抗酒精和抗焦虑的特性。GET73 对谷氨酸在海马的传递有显著的影响。
货号:ajcx34800
CAS:202402-01-5
分子式:C13H16F3NO2
分子量：275.27
溶解度:DMSO : 100 mg/mL (363.28 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].

GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production[1].

GET73 (5-50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test[3].

[1]. Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35.
[2]. Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71.
[3]. Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8.