IACS-8803 disodium 是一种高效环状二核苷酸的 STING 激动剂，具有强大的全身抗肿瘤作用。
货号:ajcx34016
CAS:2243079-36-7
分子式:C20H23FN10Na2O9P2S2
分子量：738.51
溶解度:H2O : 56.67 mg/mL (76.74 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy[1].

IACS-8803 (10 µg; intra-tumoral injection) shows superior antitumor activity in mice bearing bilateral B16-OVA melanomas[1].

[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.