XL092 是有效的 Axl，Mer 和 C-Met 激酶活性的抑制剂，IC50 分别均<10 nm。xl092 具有抗肿瘤活性，具有研究激酶依赖性疾病和病症的潜力。
货号:ajcx33382
CAS:2367004-54-2
分子式:C29H25FN4O5
分子量：528.53
溶解度:DMSO : 25 mg/mL (47.30 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

XL092 is a potent inhibitor of the activity of Axl, Mer and C-Met kinase with IC50s of<10 nM, respectively. XL092 exhibits anti-tumor activity and has the potential for kinase-dependent diseases and conditions research[1].

XL092 (compound 8; 3 mg/kg; iv) has a T1/2 of 5.4 hours, a CL of 43 mL/hr•kg. XL092 (3 mg/kg; po) has a T1/2 of 7.1 hours and a Cmax of 11.4 μM for rats[1].

[1]. Lynne Canne Bannen, et al. Compounds for the treatment of kinase-dependent disorders. WO2019148044A1.