Ceapin-A7是一种内质网应激ATF6α信号的选择性阻断剂，其IC50值为0.59μM。Ceapin-A7可用于探讨ATF6α促细胞活化的机制及其在病理环境中的作用。
货号:ajcx32096
CAS:2323027-38-7
分子式:C20H12F6N4O3
分子量：470.32
溶解度:DMSO: 100 mg/mL (212.62 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings[1].

Ceapin-A7 sensitizes cells to ER stress[1].Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β[1].

[1]. Ciara M Gallagher, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife. 2016; 5: e11878.