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Salcaprozate sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Salcaprozate sodium图片
规格:98%
分子量:301.31
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
500mg电议

产品介绍
Salcaprozatesodium(SNAC)是一种口服吸收促进剂,有潜力作为口服形式的肝素和胰岛素的递送剂。Salcaprozatesodium可增加非共价大分子络合引起的亲脂性,从而增加小肠上皮细胞的被动跨细胞渗透。
货号:ajcx31438
CAS:203787-91-1
分子式:C15H20NNaO4
分子量:301.31
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL[3].SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution[3].

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats[3].SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident[1].SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d[1]. Animal Model: Sprague-Dawley rats (6-7 weeks)[1]

[1]. Riley MGI, et, al. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats. Int J Toxicol. Jul-Aug 2009; 28(4):278-93. [2]. Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10). Pharmaceutics. 2019 Feb 13; 11(2):78. [3]. Li Y, et, al. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules. 2018 Nov 16; 23(11):2990.