MLS000532223是一种选择性的，具有高亲和力的Rho家族GTPases(RhofamilyGTPases)抑制剂，其EC50范围为16-120μM。MLS000532223能阻止GTP与几种GTPases相结合。小GTPases是细胞活性的关键调节因子。
货号:ajcx31088
CAS:16616-39-0
分子式:C15H9NO3
分子量：251.24
溶解度:DMSO: 50 mg/mL (199.01 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases. Small GTPases are key regulators of cellular activity [1].

MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner[1].MLS000532223 modulates Rho-family GTP-binding kinetics[1].MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation[1].MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation[1].MLS000532223 (10 μM) modulates actin remodeling in mast cells[1].MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells[1].

[1]. Zurab Surviladze, et al. Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J Biomol Screen. 2010 Jan;15(1):10-20.