ML406是一种小分子探针，可通过抑制M.tuberculosisBioA(DAPA合酶)来发挥抗结核活性，IC50为30nM。M.tuberculosisBioA是一种参与结核分枝杆菌中生物素生物合成的酶。
货号:ajcx31084
CAS:774589-47-8
分子式:C20H20N2O4
分子量：352.38
溶解度:DMSO: 100 mg/mL (283.78 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis[1].

ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB)[1].

[1]. Dominick Casalena, et al. Discovery of small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition. January 16, 2015.