GAKinhibitor49是一种ATP竞争性的、高选择性细胞周期蛋白G相关激酶(GAK)抑制剂，Ki为0.54nM，细胞IC50为56nM。GAKinhibitor49也显示与RIPK2结合。
货号:ajcx30694
CAS:319492-82-5
分子式:C20H22N2O5
分子量：370.4
溶解度:DMSO: 50 mg/mL (134.99 mM; ultrasonic and warming and heat to 80°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2[1].

GAK inhibitor 49 (compound 49) shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100μM, respectively[1].

[1]. Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66.