DOTA-PEG5-azide是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
货号:ajcx30554
CAS:N/A
分子式:C28H52N8O12
分子量：692.76
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DOTA-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562