规格: | 98% |
分子量: | 2477.2 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Background:
Pexiganan is a synthetic antimicrobial peptide.1It is active against various clinical isolates of bacteria from patients with diabetic foot infections, includingS. aureus, methicillin-resistantS. aureus(MRSA), andP. aeruginosa(MICs = 16-32, 16-32, and 8-16 µg/ml, respectively). Pexiganan (1 mg/kg) decreases lethality in a mouse model of sepsis induced byA. baumannii.2
1.Flamm, R.K., Rhomberg, P.R., Simpson, K.M., et al.In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanismsAntimicrob. Agents Chemother.59(3)1751-1754(2015) 2.Cirioni, O., Simonetti, O., Pierpaoli, E., et al.Enhanced efficacy of combinations of pexiganan with colistin versus Acinetobacter Baumannii in experimental sepsisShock46(2)219-225(2016)