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[Pro3]-GIP(Mouse)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
[Pro3]-GIP(Mouse)图片
包装:1mg
规格:98%
市场价:5560元
分子量:4971.62

产品介绍
GIP receptor antagonist
货号:ajcx27262
CAS:N/A
分子式:C225H342N62O64S
分子量:4971.62
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/ob mice.


Irwin et al (2007) Early administration of the glucose-dependent Insotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 50 1532 PMID:17486314 |Gault et al (2002) Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent Insotropic polypeptide. Biochem.Biophys.Res.Commun. 290 1420 PMID:11820780