SN-38 葡糖苷酸是抗癌药物伊立替康的无活性代谢物。伊立替康是一种拓扑异构酶 I 抑制剂，可用于研究结肠癌和直肠癌。
货号:ajcx26446
CAS:121080-63-5
分子式:C28H28N2O11
分子量：568.5
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SN-38 Glucuronide is a phase II metabolite of irinotecan .¹It is formedviaglucuronidation of the irinotecan phase I metabolite SN-38 by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1.

1.Hirose, K., Kozu, C., Yamashita, K., et al.Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 geneOncol. Lett.3(3)694-698(2012)