An internal standard for the quantification of carazolol
货号:ajcx26072
CAS:1173021-02-7
分子式:C18H15D7N2O2
分子量：305.4
溶解度:DMSO: slightly,Methanol: very slightly
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Carazolol-d7 is intended for use as an internal standard for the quantification of carazolol by GC- or LC-MS. Carazolol is a β-adrenergic receptor (β-AR) ligand (K_ds = 0.2, 0.03, and 4.47 nM for the human β₁-, β₂-, and β₃-ARs, respectively).¹It reduces epinephrine-induced increases in mean arterial blood pressure and heart rate in conscious pigs when administered at a dose of 10 µg/kg.²Carazolol has been found in wastewater effluent.³Formulations containing carazolol have been used to reduce stress in livestock during transport.

1.Baker, J.G.The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptorsBr. J. Pharmacol.160(5)1048-1061(2010) 2.Gregory, N.G., and Wilkins, L.J.The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigsVet. Res. Commun.5(3)277-283(1982) 3.Ternes, T.A.Occurrence of drugs in German sewage treatment plants and riversWater Res.32(11)3245-3260(1998)