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Roxatidine-d10(hemioxalate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Roxatidine-d10(hemioxalate)图片
规格:98%
分子量:361.5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of roxatidine
货号:ajcx25248
CAS:N/A
分子式:C17H16D10N2O3·1/2C2H2O4
分子量:361.5
溶解度:DMSO: soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Roxatidine-d10is intended for use as an internal standard for the quantification of roxatidine by GC- or LC-MS. Roxatidine is a histamine H2receptor antagonist and major active metabolite of roxatidine acetate .1Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50= 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2= 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin .2


1.Sewing, K.-F., Beil, W., and Hannemann, H.Comparative pharmacology of histamine H2-receptor antagonistsDrugs35(Suppl. 3)25-29(1988) 2.Umegaki, E., Yoda, Y., Tokioka, S., et al.Protective effect of roxatidine against indomethacininduced small intestinal mucosal injury in ratsJ. Gastroenterol. Hepatol.25(Suppl. 1)S35-S40(2010)