规格: | 98% |
分子量: | 317.4 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
Background:
Phenylbutazone-d9is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50= ~100 µM in the presence of hydrogen peroxide).1It also inhibits prostaglandin I synthase (IC50= ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.2Formulations containing phenylbutazone have been used in the treatment of lameness in horses.
1.Reed, G.A., Griffin, I.O., and Eling, T.E.Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolismMol. Pharmacol.27(1)109-114(1985) 2.de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al.In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitisVet. J.201(1)51-56(2014)