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Phenylbutazone-d9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenylbutazone-d9图片
规格:98%
分子量:317.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of phenylbutazone
货号:ajcx25234
CAS:1189479-75-1
分子式:C19H11D9N2O2
分子量:317.4
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Phenylbutazone-d9is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50= ~100 µM in the presence of hydrogen peroxide).1It also inhibits prostaglandin I synthase (IC50= ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.2Formulations containing phenylbutazone have been used in the treatment of lameness in horses.


1.Reed, G.A., Griffin, I.O., and Eling, T.E.Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolismMol. Pharmacol.27(1)109-114(1985) 2.de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al.In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitisVet. J.201(1)51-56(2014)