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Racecadotril-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Racecadotril-d5图片
规格:98%
分子量:390.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An internal standard for the quantification of racecadotril
货号:ajcx25194
CAS:1246815-11-1
分子式:C21H18D5NO4S
分子量:390.5
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Racecadotril-d5is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan .1,2In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively.1It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea.2Formulations containing racecadotril have been used in the treatment of acute diarrhea.


1.Griggs, D.W., Prinsen, M.J., Oliva, J., et al.Pharmacologic comparison of clinical neutral endopeptidase inhibitors in a rat model of acute secretory diarrheaJ. Pharmacol. Exp. Ther.357(2)423-431(2016) 2.Bui, T., Li, G., Kim, I., et al.Effects of racecadotril on weight loss and diarrhea due to human rotavirus in neonatal gnotobiotic pigs (Sus scrofa domesticus)Comp. Med.67(2)157-164(2017)