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UGT8 Inhibitor 19
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UGT8 Inhibitor 19图片
规格:98%
分子量:528.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An inhibitor of UGT8
货号:ajcx25048
CAS:2414349-93-0
分子式:C20H22F6N4O4S
分子量:528.5
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 25 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

UGT8 inhibitor 19 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT; IC50= 0.2 nM).1It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 µM for all).In vivo, UGT8 inhibitor 19 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s =<3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.


1.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020)