Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素，来源于病原体真菌疣状真菌 Myrothecium verrucaria，是蛋白质合成的抑制剂。 Verrucarin A 抑制白血病细胞系的生长并激活巨噬细胞中的半胱天冬酶和凋亡和炎症信号。 Verrucarin A 有效增加 p38 MAPK 的磷酸化并减少 ERK/Akt 的磷酸化。 Verrucarin A 通过诱导 p21 和 p53 引起细胞周期失调。
货号:ajcx23724
CAS:3148-09-2
分子式:C27H34O9
分子量：502.6
溶解度:Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Verrucarin A is a macrocyclic trichothecene that has been found inM. verrucariaand has diverse biological activities.^1,2,3,4It induces apoptosis and production of reactive oxygen species (ROS) in MDA-MB-231 and T47D breast cancer cells when used at concentrations ranging from 100 to 500 ng/ml.¹Verrucarin A enhances LPS-induced secretion of IL-1β and IL-18 in macrophage-differentiated peripheral blood mononuclear cells (PBMCs).²It inhibits the growth of the multidrug-resistantP. falciparumstrain K1 (EC₅₀= 0.9 ng/ml).³Verrucarin A is active againstM. incognitaroot-knot nematodes (MIC = 1.88 µg/ml).⁴

1.Palanivel, K., Kanimozhi, V., Kadalmani, B., et al.Verrucarin A, a protein synthesis inhibitor, induces growth inhibition and apoptosis in breast cancer cell lines MDA-MB-231 and T47DBiotechnol. Lett.35(9)1395-1403(2013) 2.Kankkunen, P., Rintahaka, J., Aalto, A., et al.Trichothecene mycotoxins activate inflammatory response in human macrophagesJ. Immunol.182(10)6418-6425(2009) 3.Isaka, M., Punya, J., Lertwerawat, Y., et al.Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucariaJ. Nat. Prod.62(2)329-331(1999) 4.Nguyen, L.T.T., Jang, J.Y., Kim, T.Y., et al.Nematicidal activity of verrucarin A and roridin A isolated from Myrothecium verrucaria against Meloidogyne incognitaPestic. Biochem. Physiol.148133-143(2018)