| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 4074元 |
| 分子量: | 378.5 |
Background:
Prasugrel-d5is intended for use as an internal standard for the quantification of prasugrel by GC- or LC-MS. Prasugrel is a prodrug form of the platelet purinergic P2Y12receptor antagonist R-99224.1Prasugrel (0.3 and 3 mg/kg) inhibitsex vivowashed platelet aggregation in rat platelet rich-plasma.2In vivo, prasugrel prevents thrombus formation (ED50= 0.68 mg/kg) and increases tail bleeding time in rats. Formulations containing prasugrel have been used in the prevention of blood clots.
1.Sugidachi, A., Asai, F., Yoneda, K., et al.Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type Gi-linked P2T antagonist, CS-747Br. J. Pharmacol.132(1)47-54(2001) 2.Sugidachi, A., Asai, F., Ogawa, T., et al.The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist propertiesBr. J. Pharmacol.129(7)1439-1446(2000)
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