An internal standard for the quantification of oleoyl ethanolamide
货号:ajcx23174
CAS:946524-36-3
分子式:C20H35D4NO2
分子量：329.6
溶解度:DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 100 μg/ml
纯度：98%
存储：Store at -20°C
库存：
现货Background:
Oleoyl ethanolamide-d4contains four deuterium atoms at the hydroxyethyl 1,1',2, and 2' positions. It is intended for use as an internal standard for the quantification of oleoyl ethanolamide by GC-or LC-mass spectrometry. Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate.1It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,2but its biosynthesis is reduced in the intestine of rats following food deprivation.3OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50value of 120 nM in a transactivation assay.4Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.3,4These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.
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2.Epps, D.E., Palmer, J.W., Schmid, H.H.O., et al.Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acelethanolamines, a class of lipids synthesized in ischemic heart tissueThe Journal of Biological Chemisty2571383-1392(1982)
3.de Fonseca, F.R., Navarro, M., GÓmez, R., et al.An anorexic lipid mediator regulated by feedingNature414209-212(2001)
4.Fu, J., Gaetani, S., Oveisi, F., et al.Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-αNature42590-93(2003)
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