A neuropeptide with diverse biological activities
货号:ajcx22512
CAS:N/A
分子式:C26H31D4F3O6
分子量：504.6
溶解度:DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fluprostenol isopropyl ester-d₄is intended for use as an internal standard for the quantification of fluprostenol isopropyl ester by GC- or LC-MS. Fluprostenol isopropyl ester is an analog of prostaglandin F_2αand an isopropyl ester prodrug form of (+)-fluprostenol .^1,2Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC₅₀value of 40.2 nM.³Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.²It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.

1.Sorbera, L.A., and CastaÑer, J.TravoprostDrugs Future25(1)41-45(2000) 2.Hellberg, M.R., Sallee, V.L., McLaughlin, M.A., et al.Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonistJ. Ocul. Pharmacol. Ther.17(5)421-432(2001) 3.Sharif, N.A., Kelly, C.R., Crider, J.Y., et al.Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cellsJ. Ocul. Pharmacol. Ther.19(6)501-515(2003)