A bacterial metabolite with antibacterial and anticancer activities
货号:ajcx22390
CAS:79127-35-8
分子式:C10H9NO5
分子量：223.2
溶解度:DMF: soluble,Methanol: soluble,Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Echinosporin is a bacterial metabolite originally isolated fromStreptomyces echinosporusthat has antibacterial and anticancer activities.^1,2,3It is active againstP. vulgaris,S. typhosa,S. sonnei,E. coli, andB. subtilis(MICs = 100, 100, 100, 200, and 400 µg/ml, respectively).¹Echinosporin induces cell cycle arrest at the G₂/M phase and apoptosis in, as well as inhibits proliferation of, HCT-15 human colorectal cancer cells (IC₅₀s = 1.7, 1.75, and 247 µM, respectively).²It inhibits tumor growth in murine P388 leukemia and Meth 1 fibrosarcoma models when administered at doses ranging from 10 to 80 mg/kg.³

1.Sato, T., Kawamoto, I., Oka, T., et al.A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterizationJ. Antibiot. (Tokyo)35(3)266-271(1982) 2.Cui, C.B., Liu, H.B., Gu, J.Y., et al.Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolusFitoterapia78(3)238-240(2007) 3.Morimoto, M., and Imai, R.Antitumor activity of echinosporinJ. Antibiot. (Tokyo)38(4)490-495(1985)