A neuropeptide with diverse biological activities
货号:ajcx21892
CAS:N/A
分子式:C46H84D3NO13
分子量：865.2
溶解度:Chloroform:Methanol:Water (5:1:0.1): soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C16 Lactosylceramide-d₃(d18:1/16:0-d₃) is intended for use as an internal standard for the quantification of C16 lactosylceramide by GC- or LC-MS. C16 Lactosylceramide is an endogenous bioactive sphingolipid.¹It forms membrane microdomains with Lyn kinase and the α_isubunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle.²C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.³[Matreya, LLC. Catalog No. 1534]

1.Iwabuchi, K., Nakayama, H., Oizumi, A., et al.Role of ceramide from glycosphingolipids and its metabolites in immunological and inflammatory responses in humansMediators Inflamm.2015120748(2015) 2.Rico, J.E., Bandaru, V.V., Dorskind, J.M., et al.Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactationJ. Dairy Sci.98(11)7757-7770(2015) 3.Praggastis, M., Tortelli, B., Zhang, J., et al.A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease alleleJ. Neurosci.35(21)8091-8106(2015)