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18-Deoxyherboxidiene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
18-Deoxyherboxidiene图片
规格:98%
分子量:422.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
18-Deoxyherboxidiene (RQN-18690A) 是一种有效的血管生成抑制剂。
货号:ajcx21166
CAS:1200128-66-0
分子式:C25H42O5
分子量:422.6
溶解度:DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

18-Deoxyherboxidiene is a bacterial metabolite that has been found inStreptomycesQN18690 and has antiangiogenic activity.1It binds to the SF3b subunit of spliceosome-associated protein 130 (SAP130), SAP145, or SAP155 in HeLa cell extracts when used at 100, 1,000, and 10,000 ng and induces the accumulation of unspliced mRNA in HEK293T cells in a reporter assay. 18-Deoxyherboxidiene inhibits VEGF-induced migration of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner and VEGF-induced HUVEC tube formation when used at a concentration of 0.3 µg/ml.


1.Kakeya, H., Kaida, D., Sekiya, H., et al.RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesisJ. Antibiot. (Tokyo)69(2)121-123(2016)