A neuropeptide with diverse biological activities
货号:ajcx21132
CAS:N/A
分子式:C20H19D9O3
分子量：325.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

15-deoxy-δ^12,14-Prostaglandin J₂-d₉(15-deoxy-δ^12,14-PGJ₂-d₉) is intended for use as an internal standard for the quantification of 15-deoxy-δ^12,14-PGJ₂by GC- or LC-MS. 15-deoxy-δ^12,14-PGJ₂is formed from PGD₂by the elimination of two molecules of water. It binds selectively to PPARγ with an EC₅₀value of 2 µM in a murine chimera system.^1,215-deoxy-δ^12,14-PGJ₂is more potent than PGD₂, δ¹²-PGJ₂, and PGJ₂in stimulating lipogenesis in C3H10T1/2 cells. The EC₅₀for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.¹

1.Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al.A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiationCell83(5)813-819(1995) 2.Forman, B.M., Tontonoz, P., Chen, J., et al.15-Deoxy-δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell83(5)803-812(1995)