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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:1347元
分子量:1516.8

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx20970
CAS:N/A
分子式:C79H109N19O12.XCF3COOH
分子量:1516.8
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P (SPD-D) is an analog of substance P and a broad-spectrum neuropeptide antagonist with anticancer activity.1It blocks intracellular calcium increases induced by vasopressin, bradykinin , gastrin , and galanin in H-510 small cell lung carcinoma (SCLC) cells. SPD-D also blocks vasopressin- and bradykinin-induced MAPK signaling in H-510 SCLC cells in a concentration-dependent manner. It inhibits DNA synthesis in a panel of cancer cell lines (IC50s = 20-50 μM) and reduces colony formation of HC12, ICR-SC112, HX149, and NCI-H226 cancer cellsin vitro(IC50s = 0.5-6.5 μM).2In vivo, SPD-D (2.1 μg, s.c.) inhibits tumor growth in HC12 and ICR-SC112 SCLC mouse xenograft models.3


1.Seckl, M.J., Higgins, T., Widmer, F., et al.[D-Arg1,D-Trp5,7,9,Leu11]substance P: A novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cellsCancer Res.57(1)51-54(1997) 2.Everard, M.J., Macaulay, V.M., Miller, J.L., et al.In vitro effects of substance P analogue [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P on human tumour and normal cell growthBr. J. Cancer65(3)388-392(1992) 3.Everard, M.J., Macaulay, V.M., Millar, J.L., et al.[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P inhibits the growth of human small cell lung cancer xenografts in vivoEur. J. Cancer29A(10)1450-1453(1993)