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(±)-Felodipine-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-Felodipine-d5图片
包装:1mg
规格:98%
市场价:6297元
分子量:389.3

产品介绍
An internal standard for the quantification of (±)-felodipine
货号:ajcx20870
CAS:1242281-38-4
分子式:C18H14Cl2D5NO4
分子量:389.3
溶解度:Chloroform: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(±)-Felodipine-d5is intended for use as an internal standard for the quantification of (±)-felodipine by GC- or LC-MS. (±)-Felodipine is an inhibitor of L-type calcium channels.1It induces relaxation of precontracted isolated porcine coronary artery segments (EC50= 0.15 nM), which highly express L-type calcium channels.2(±)-Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Cav3.2 channel (IC50= 6.8 µM).1,3(±)-Felodipine preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively).4It decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation when administered intravenously at doses of 30 and 100 nmol/kg.5


1.Furukawa, T., Yamakawa, T., Midera, T., et al.Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytesJ. Pharmacol. Exp. Ther.291(2)464-473(1999) 2.Johnson, J.D., and Fugman, D.A.Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segmentsJ. Pharmacol. Exp. Ther.226(2)330-334(1983) 3.Perez-Reyes, E., Van Deusen, A.L., and Vitko, I.Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: Block by antihypertensives, antiarrhythmics, and their analogsJ. Pharmacol. Exp. Ther.328(2)621-627(2009) 4.Ljung, B.Vascular selectivity of felodipine: Experimental pharmacologyJ. Cardiovasc. Pharmacol.15(Suppl 4)S11-S16(1990) 5.Bolt, G.R., and Saxena, P.R.Acute systemic and regional hemodynamic effects of felodipine, a new calcium antagonist, in conscious renal hypertensive rabbitsJ. Cardiovasc. Pharmacol.6(4)707-712(1984)