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ML-396
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML-396图片
规格:98%
分子量:360.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A positive allosteric modulator of group III mGluRs
货号:ajcx20668
CAS:1630936-95-6
分子式:C17H11Cl2N3O2
分子量:360.2
溶解度:Chloroform: slightly soluble,DMSO: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays.1 ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.2


|1. Jalan-Sakrikar, N., Field, J.R., Klar, R., et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem. Neurosci. 5(12), 1221-1237 (2014).|2. Gogliotti, R.G., Senter, R.K., Fisher, N.M., et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci. Transl. Med. 9(403), (2017).